Spastic Paraplegia in Middle Age

Spastic Paraplegia in Middle Age.

Hereditary spastic paraplegia.

Hereditary spastic paraplegia (HSP) or Strümpell-Lorrain syndrome is a heterogeneous group of inherited disorders, with prevalence ranged from 4.3 to 9.6 cases per 100,000 population. A common feature of these disorders is the slowly progressive and often severe spasticity, noticeably especially in the low limbs. Conventionally, HSP is divided into two clinical groups, uncomplicated (pure spast...

Hereditary Spastic Paraplegia.

111 families, and Paskind and Stone (1933) also summarized the literature with accounts of another 36 reports from 40 families. Since then about 50 further reports have appeared, covering some 60 families, bringing the total so far to 176 reports of 215 families. Of these the majority have originated in Germany or elsewhere in Europe, but with a substantial number from the Americas. In Britain,...

Subdural Hematoma and Spastic Paraplegia

This is a case of progressive lower limb weakness in a 72-year-old man secondary to chronic bilateral subdural hematoma. This patient presented with a 3 week history of progressive difficulty in walking, with upper motor neuron signs but no sensory deficit. He had no significant risk factors for chronic subdural hematoma. Literature search revealed only one similar documented case of painless b...

Cerebellar degeneration in dominantly inherited spastic paraplegia.

The clinical features of five affected members in three generations of a family with dominantly inherited Strumpell's spastic paraplegia are described, together with the pathological findings in two cases. The late presentation and slow progression of the disease encompass features of the types I and II of other authors illustrating the heterogeneous expression of the disorder. Cerebellar invol...